the surface

the surface

What is Alport Syndrome?

Alport syndrome is a rare genetic condition responsible for a defective glomerular basement membrane (GBM), causing chronic inflammation, tissue fibrosis, and end-stage kidney disease.1,3-6

Highlight What May Be Hiding In Plain Sight

The signs of Alport syndrome can vary from patient to patient.7 Accurately diagnose Alport syndrome by highlighting the following signs:

  • Hematuria
  • Inflammation
  • GFR decline
  • History of Family CKD
CKD=chronic kidney disease.

Hematuria

  • Hematuria is not just a late-stage sign of the condition7
  • At-risk males and females who present later in life with hematuria, but without other characteristics, may be misdiagnosed8
  • Persistent hematuria is the cardinal feature of Alport syndrome9

Inflammation

  • Inflammation is a central element of chronic kidney disease progression5
  • Alport syndrome progresses due to ongoing damage from chronic inflammation in the kidneys1,3,5,6
  • Inflammation is a common mechanism underlying progression to end-stage kidney disease5

GFR decline

  • All forms of chronic kidney disease are characterized by progressive loss in glomerular filtration rate (GFR); Alport syndrome is no exception10
  • Consider Alport syndrome when you detect GFR decline, particularly when accompanied by a family history of AS or CKD, to help manage progression sooner11
  • GFR decline is a clear marker of progression10

Family History of CKD

  • Alport syndrome is an inherited chronic kidney disease (CKD) that can affect multiple members of a family7
  • If you suspect Alport syndrome in a family, earlier diagnosis can be achieved through genetic testing12
  • Alport syndrome can filter through a family7
See how the signs of Alport syndrome affect different people.

Behind the Mystery:
Disease Definition

Watch this video for an overview of Alport syndrome and learn how you can identify patients living with the condition.

Test your knowledge on
Alport syndrome

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